Process for measuring low cadmium levels in blood and other biological specimens
AssigneeThe United States of America as represented by the United States Department of Energy
InventorsDavid P. Peterson, Edmund A. Huff, Maryka H. Bhattacharyya
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Abstract
A process for measuring low levels of cadmium in blood and other biological specimens is provided without interference from high levels of alkali metal contaminants by forming an aqueous solution and without contamination by environmental cadmium absent the proteins from the specimen, selectively removing cadmium from the aqueous solution on an anion exchange resin, thereby removing the alkali metal contaminants, resolubilizing cadmium from the resin to form a second solution and analyzing the second solution for cadmium, the process being carried out in a cadmium-free environment.
Claims9
A process for measuring half microgram levels of cadmium in biological fluids containing at least one alkali metal contaminant, comprising
- the steps of forming an aqueous solution of cadmium and the contaminant from a sample of the fluid converting the cadmium to anionic cadmium chloride selectively removing cadmium apart from a substantial portion of the contaminant from the aqueous solution on an anion exchange resin, resolubilizing cadmium from the resin to form a second solution, and analyzing for cadmium in the second solution, the process being carried out in an essentially cadmium-free environment.
A process for measuring half microgram levels of cadmium in biological fluids containing at least one alkali metal contaminant, comprising
- the steps of forming an aqueous solution of cadmium and the contaminant from a sample of the fluid, selectively removing cadmium apart from a substantial portion of the contaminant from the aqueous solution on an anion exchange resin, resolubilizing cadmium from the resin to form a second solution, and analyzing for cadmium in the second solution, the process being carried out in an essentially cadmium-free environment,
- the cadmium content of the second solution being increased by increasing the volume of the aqueous solution compared to the volume of the second solution, and a corrective factor for Zn being applied to correct for the limiting value of Zn on the analyzed value for cadmium.
Dependencies are inferred from the claim text.