Uses of conjugates of GM-CSF and IL-7 to treat viral infections
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsJacques Galipeau, Hsiang-Chuan Hsieh
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Abstract
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.
Claims1
A method of treating a viral infection comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising a conjugate comprising a GM-CSF polypeptide and an IL-7 polypeptide, and having the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.