Mineral amino-acid complexes of active agents
AssigneeThetis Pharmaceuticals LLC
InventorsFrank C. Sciavolino, Gary Mathias
Life of this patent
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Abstract
The present invention provides compounds of Formula I and related compositions and methods.
Claims57
A compound of Formula I which is a mono or bis salt of a polyunsaturated fatty acid having an amino acid component, which consists of two amino acid moieties coordinated around a divalent metal cation, a metal component, which consists of a divalent metal cation, and a counter-ion component, which consists of one or two additional molecules, A and B, ionically bound to the amino acid component,
- wherein
- R1 and R2 each refer to a branched or unbranched carbon chain of from 1 to 20 carbons having at least one basic function;
- R1 and R2 are the same or different and the at least one basic function is independently selected from a primary amine, a secondary amine, a tertiary amine, and a guanidine;
- X1 and X2 are independently selected from H and —CO—Z, where Z is a peptide moiety incorporating from 1 to 5 amino acids, or a pharmaceutically acceptable salt thereof;
- X1 and X2 are the same or different;
- M is a divalent metal cation selected from magnesium (Mg2+), calcium (Ca2+), and zinc (Zn2+);
- A and B are each independently selected from a polyunsaturated fatty acid having 16 to 24 carbon atoms
- either A or B, but not both, may be absent, and
- when both A and B are present, A and B may be the same or different.
A compound of Formula I which is a bis salt of a polyunsaturated fatty acid having an amino acid component, which consists of two amino acid moieties coordinated around a divalent metal cation, a metal component, which consists of a divalent metal cation, and a counter-ion component, which consists of one or two additional molecules, A and B, ionically bound to the amino acid component,
- wherein
- R1 and R2 are each (CH2)4—NH3+;
- X1 and X2 are each H;
- M is magnesium (Mg2 +);
- and
- A and B are each eicosapentaenoic acid (EPA).
A compound of Formula I which is a bis salt of a polyunsaturated fatty acid having an amino acid component, which consists of two amino acid moieties coordinated around a divalent metal cation, a metal component, which consists of a divalent metal cation, and a counter-ion component, which consists of one or two additional molecules, A and B, ionically bound to the amino acid component,
- wherein
- R1 and R2 are each (CH2)4—NH3+;
- X1 and X2 are each H;
- M is magnesium (Mg2+);
- and
- A and B are each docosahexaenoic acid (DHA).
A compound of Formula I which is a bis salt of a polyunsaturated fatty acid having an amino acid component, which consists of two amino acid moieties coordinated around a divalent metal cation, a metal component, which consists of a divalent metal cation, and a counter-ion component, which consists of one or two additional molecules, A and B, ionically bound to the amino acid component,
- wherein
- R1 and R2 are each (CH2)4—NH3+;
- X1 and X2 are each H;
- M is magnesium (Mg2+);
- and
- A and B are each docosapentaenoic acid (DPA).
Dependencies are inferred from the claim text.