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US 9,999,361 B2Granted
Method and system for non-invasive assessment of coronary artery disease
AssigneeSiemens Healthcare GmbH
InventorsPuneet Sharma, Bogdan Georgescu, Viorel Mihalef, Terrence Chen, Dorin Comaniciu
Life of this patent
Estimating the term…
Abstract
In order to assess coronary artery disease from medical image data, an anatomical model of a coronary artery is generated from the medical image data. A velocity of blood in the coronary artery is estimated based on a spatio-temporal representation of contrast agent propagation in the medical image data. Blood flow is simulated in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
Claims19
A method of non-invasive assessment
- coronary flow reserve (CFR) using medical image data, comprising:
- receiving a first sequence of medical image data acquired during a resting state using a computed tomography (CT) scanner or an X-ray image acquisition device and a second sequence of medical image data acquired during hyperemia using a computed tomography (CT) scanner or an X-ray image acquisition device;
- generating a first anatomical model of a coronary artery from the first sequence of medical image data and a second anatomical model of the coronary artery from the second sequence of medical image data;
- estimating a maximum velocity of blood on a cross-section of the coronary artery during the resting state based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the first sequence of medical image data and estimating a maximum velocity of blood on the cross-section of the coronary artery during hyperemia based on a spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the second sequence of medical image data;
- mapping the maximum velocity of the blood on the cross-section of the coronary artery during the resting state to an average rest velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery during the resting state using patient-specific mapping parameters, and mapping the maximum velocity of the blood on the cross-section of the coronary artery during hyperemia to an average hyperemia velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery during hyperemia using patient-specific mapping parameters;
- and
- calculating the coronary flow reserve for the coronary artery based on the average rest velocity and the average hyperemia velocity.
4 more elements
An apparatus for non-invasive assessment coronary flow reserve (CFR) using medical image data, comprising:
- a processor;
- and
- a memory storing computer program instructions, which when executed by the processor cause the processor to perform operations comprising:
- receiving a first sequence of medical image data acquired during a resting state using a computed tomography (CT) scanner or an X-ray image acquisition device and a second sequence of medical image data acquired during hyperemia using a computed tomography (CT) scanner or an X-ray image acquisition device;
- generating a first anatomical model of a coronary artery from the first sequence of medical image data and a second anatomical model of the coronary artery from the second sequence of medical image data;
- estimating a maximum velocity of blood on a cross-section of the coronary artery during the resting state based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the first sequence of medical image data and estimating a maximum velocity of blood on the cross-section of the coronary artery during hyperemia based on a spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the second sequence of medical image data;
- mapping the maximum velocity of the blood on the cross-section of the coronary artery during the resting state to an average rest velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery during the resting state using patient-specific mapping parameters and mapping the maximum velocity of the blood on the cross-section of the coronary artery during hyperemia to an average hyperemia velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery during hyperemia using patient-specific mapping parameters;
- and
- calculating the coronary flow reserve for the coronary artery based on the average rest velocity and the average hyperemia velocity.
6 more elements
A non-transitory computer readable medium comprising computer executable instructions for performing non-invasive assessment coronary flow reserve (CFR) using medical image data, the computer executable instructions performing steps comprising:
- receiving a first sequence of medical image data acquired during a resting state using a computed tomography (CT) scanner or an X-ray image acquisition device and a second sequence of medical image data acquired during hyperemia using a computed tomography (CT) scanner or an X-ray image acquisition device;
- generating a first anatomical model of a coronary artery from the first sequence of medical image data and a second anatomical model of the coronary artery from the second sequence of medical image data;
- estimating a maximum velocity of blood on a cross-section of the coronary artery during the resting state based on a spatio-temporal representation of contrast agent propagation over a length of the coronary artery in the first sequence of medical image data and estimating a maximum velocity of blood on the cross-section of the coronary artery during hyperemia based on a spatio-temporal representation of contrast agent propagation over the length of the coronary artery in the second sequence of medical image data;
- mapping the maximum velocity of the blood on the cross-section of the coronary artery during the resting state to an average rest velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery during the resting state using patient-specific mapping parameters, and mapping the maximum velocity of the blood on the cross-section of the coronary artery during hyperemia to an average hyperemia velocity representing a spatial average of a velocity profile over the cross-section of the coronary artery during hyperemia using patient-specific mapping parameters;
- and
- calculating the coronary flow reserve for the coronary artery based on the average rest velocity and the average hyperemia velocity.
3 more elements
Dependencies are inferred from the claim text.