Water-borne antimicrobial formulations with hydrogen peroxide
AssigneeQuick-Med Technologies, Inc.
InventorsWilliam Toreki, Rustom S. Kanga
Life of this patent
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Abstract
This invention relates to regenerable antimicrobial coatings with long-lasting efficacy for use in medical applications including implants, medical instruments or devices, and hospital equipment. The same coatings would also have broad utility in the consumer, industrial, and institutional markets. The coating technology would be based on sequestration of hydrogen peroxide (HP) by zinc oxide binders incorporated into the coatings.
Claims20
A water-borne formulation for imparting durable antimicrobial activity to a substrate, wherein said water-borne formulation is an aqueous dispersion comprising:
- a. a metal derivative, wherein said metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from the group consisting of zinc, magnesium, titanium, and zirconium,
- b. a polymer, wherein the water absorbency of said polymer is between 0.5% and 20% (w/w), and
- c. hydrogen peroxide,
- wherein the metal derivative comprises up to 10% (w/w) of the formulation, wherein the polymer comprises up to 36% (w/w) of the formulation, and wherein the hydrogen peroxide concentration is between 0.5% and 10% (w/w).
A method of enhancing and regenerating durable antimicrobial activity of the surface of a substrate, wherein said method comprises the steps of:
- a. providing, on the surface of a substrate on which durable antimicrobial activity is desired, a water-borne formulation for imparting durable antimicrobial activity to a substrate, wherein said formulation comprises an aqueous dispersion of,
- i. a metal derivative, wherein said metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from the group consisting of zinc, magnesium, titanium, and zirconium,
- ii. a polymer, wherein the water absorbency of said polymer is between 0.5% and 20% (w/w), and
- iii. hydrogen peroxide, and
- b. drying said substrate,
- wherein the metal derivative comprises up to 10% of the aqueous dispersion, and wherein the polymer comprises up to 36% of the aqueous dispersion, and wherein the aqueous hydrogen peroxide has a concentration between 0.5% and 10%.
A regenerable antimicrobial water-borne coating on a substrate comprising,
- a. a metal derivative, wherein said metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from the group consisting of zinc, magnesium, titanium, and zirconium,
- b. a polymer, wherein said polymer is doped with 1% to 50% (w/w) of said metal derivative,
- c. sequestered hydrogen peroxide,
- wherein the water absorbency of said polymer is between 0.5% and 20% (w/w), wherein said polymer doped with said metal derivative has been determined to be capable of sequestering hydrogen peroxide when exposed to said source of aqueous hydrogen peroxide;
- wherein the antimicrobial activity of said doped polymer can be regenerated on subsequent exposure to aqueous hydrogen peroxide,
- whereby said antimicrobial coating, when tested using ASTM Standard Method E2180 at least 24 hours after preparation, provides at least a 3-log reduction of viable Escherichia coli bacteria greater than that of a corresponding coating which has not been exposed to hydrogen peroxide.
Dependencies are inferred from the claim text.