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US 9,994,631 B2Granted
Signal biomarkers
AssigneeUpstream Medical Technologies Limited
InventorsChristopher Joseph Pemberton, Arthur Mark Richards
Life of this patent
Estimating the term…
Abstract
Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefore.
Claims17
An antibody, or antigen-binding fragment thereof, which specifically binds a peptide of C-type natriuretic signal peptide CNPsp selected from CNPsp(1-13) peptide having an amino acid sequence consisting of SEQ ID NO:5 or CNPsp(14-23) peptide having an amino acid sequence consisting of SEQ ID No:6,
- wherein the antibody, or antigen-binding fragment thereof is immobilized on a solid matrix or is labeled.
A composition comprising:
- a first anti-C-type natriuretic signal peptide (CNPsp) antibody, or antigen-binding fragment thereof, immobilized on a solid matrix;
- a CNPsp or fragment thereof bound to the first anti-CNPsp antibody, or antigen-binding fragment thereof;
- and
- a second anti-CNPsp antibody, or antigen-binding fragment thereof, bound to the CNPsp or fragment thereof, wherein the second anti-CNPsp antibody, or antigen-binding fragment thereof, binds to a site on CNPsp or fragment thereof that is different from the site bound by the first anti-CNPsp antibody, or antigen-binding fragment thereof, wherein
- either the first or the second anti-CNPsp antibody, or antigen-binding fragment thereof, is the anti-CNPsp antibody, or antigen-binding fragment thereof, which specifically binds a peptide of CNPsp selected from CNPsp(1-13) peptide having an amino acid sequence consisting of SEQ ID NO:5 or CNPsp(14-23) peptide having an amino acid sequence consisting of SEQ ID NO:6.
2 more elements
A kit comprising:
- a first anti-C-type natriuretic signal peptide (CNPsp) antibody, or antigen-binding fragment thereof, immobilized on a solid matrix;
- and
- a second anti-CNPsp antibody, or antigen-binding fragment thereof, wherein the second anti-CNPsp antibody, or antigen-binding fragment thereof, binds to a site on CNPsp or fragment thereof that is different from the site bound by the first anti-CNPsp antibody, wherein
- either the first or the second anti-CNPsp antibody, or fragment thereof, is the anti-CNPsp antibody, or antigen-binding fragment thereof, which specifically binds a peptide of CNPsp selected from CNPsp(1-13) peptide having an amino acid sequence consisting of SEQ ID NO:5 or CNPsp(14-23) peptide having an amino acid sequence consisting of SEQ ID NO:6.
1 more element
Dependencies are inferred from the claim text.