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US 9,994,519 B2Granted
Synthetic antioxidants and their uses
OwnerYansong Luinventor
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OwnerYansong Luinventor
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The present invention relates to synthetic organic antioxidants of small molecules. The novel dithiol-containing compounds in this invention possess strongest possible capability as both scavenger for free radicals and antioxidant. This invention is directed to novel molecules as prodrugs of the novel dithiol-containing compounds, their rational design, their feasible preparation route by means of synthetic organic chemistry, and their potential uses in application to treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancer, diabetes, HIV, acne, cardiovascular disease, renal disease, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, pain, aging, stroke, cataract, glaucoma, age-related macular degeneration, etc.
A compound comprising at least one pair of functional groups that consist of one functional group as thiol (—SH), optionally acylated, and another one as either carbodithioic acid (—CSSH) or carbothioic acid (—COSH), which when oxidized can form an intramolecular 5 or 6-membered ring via a disulfide bond, wherein said one pair functional groups are each optionally protected by an independently selected protecting group that is removable under physiological conditions for the purpose of drug delivery.
Dependencies are inferred from the claim text.