Fragments of P97 and uses thereof
AssigneeBioasis Technologies, Inc.
InventorsTimothy Z. Vitalis, Reinhard Gabathuler
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Abstract
Provided are fragments of human p97 (melanotransferrin) polypeptides having blood-brain barrier (BBB) transport activity, including variants and combinations thereof, conjugates comprising the p97 fragments, and related methods of use thereof, for instance, to facilitate delivery of therapeutic or diagnostic agents across the BBB.
Claims11
A conjugate, comprising a p97 fragment that is conjugated to an antibody or antigen-binding fragment thereof optionally via a peptide linker, to form a p97-antibody conjugate, wherein the p97 fragment consists essentially of DSSHAFTLDELR (SEQ ID NO:
- 13), and wherein the antibody or antigen-binding fragment thereof specifically binds to human Her2/neu.
A conjugate, comprising a p97 fragment that is conjugated to trastuzumab, to form a p97-trastuzumab conjugate, wherein the p97 fragment consists of DSSHAFTLDELR (SEQ ID NO:
- 13) with a C-terminal tyrosine, and wherein the p97 fragment and trastuzumab are separated by a peptide linker of about 1-10 amino acids in length.
Dependencies are inferred from the claim text.