# US 9,993,398 B2 · Method for forming a dispersion comprising drops, and associated apparatus > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,993,398 B2 - Document ID: US9993398B2 - Status: Granted - Kind: B2 - Application number: 15/028,731 - Filed: 2014-10-16 - Published: 2016-09-15 - Granted: 2018-06-12 - Earliest claimed: 2013-10-17 - Assignees: Capsum - Applicants: Capsum - Inventors: Mathieu Goutayer; Yan Eric Pafumi - Web page: https://patentgrep.com/patent/US9993398B2 ## CPC - A61K 8/04: Dispersions; Emulsions - A61K 8/042: {Gels} - A61K 8/19: containing inorganic ingredients - A61K 8/31: Hydrocarbons - A61K 8/34: Alcohols - A61K 8/345: {containing more than one hydroxy group} - A61K 8/37: Esters of carboxylic acids - A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof - A61K 8/585: {Organosilicon compounds} - A61K 8/73: Polysaccharides - A61Q 13/00: Formulations or additives for perfume preparations (essential oils or perfumes per se C11B9/00) - A61Q 19/00: Preparations for care of the skin - B01F 23/40: Mixing liquids with liquids; Emulsifying - B01F 23/41: Emulsifying - B01F 23/45: using flow mixing - B01F 33/3011: using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream - B01J 13/10: Complex coacervation, i.e. interaction of oppositely charged particles - C11D 3/505: {encapsulated or adsorbed on a carrier, e.g. zeolite or clay} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - B01F: MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING (mixing paints B44D3/06) - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS - C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL ## Abstract This method comprises the following steps: flowing drops of a first phase, through a circulation duct, into a second phase that is substantially immiscible with the first phase, each drop comprising a core formed from the first phase and a shell formed from a layer of coacervate inserted between the first phase and the second phase; recovering a dispersion containing drops and the second phase in a container; injecting a solution for increasing the viscosity of the second phase in the circulation duct or at the outlet of the circulation duct, upstream from the container. ## Claims ### Claim 1 A method for forming a dispersion comprising drops, the method including: flowing drops of a first phase, through a circulation duct, into a second phase that is substantially immiscible with the first phase, each drop comprising a core formed from the first phase and a shell formed from a layer of coacervate inserted between the first phase and the second phase; recovering a dispersion containing drops and second phase in a container; injecting a solution for increasing the viscosity of the second phase in the circulation duct or at the outlet of the circulation duct, upstream from the container. ### Claim 2 (depends on 1) The method according to claim 1, wherein the drops of the second phase flow along a local axis in the circulation duct, injecting the solution increasing the viscosity being done substantially coaxially with the local axis. ### Claim 3 (depends on 1) The method according to claim 1, wherein injecting the solution increasing the viscosity includes bringing at least part of the solution increasing the viscosity to the center of the flow of the drops and the second phase. ### Claim 4 (depends on 1) The method according to claim 1, wherein injecting the solution increasing the viscosity includes bringing at least part of the solution increasing the viscosity to the periphery of the flow of the drops and the second phase. ### Claim 5 (depends on 1) The method according to claim 1, including reducing the cross-section of the flow of drops and the second phase, downstream from the injection of the solution increasing the viscosity. ### Claim 6 (depends on 5) The method according to claim 5, wherein the solution increasing the viscosity is injected at the outlet of the circulation duct. ### Claim 7 (depends on 1) The method according to claim 1, including, upstream from the flowing of the drops, forming drops in the circulation duct. ### Claim 8 (depends on 7) The method according to claim 7, wherein forming drops comprises: providing a first fluid comprising the first phase and a first precursor polymer of the coacervate contained in the first phase; forming drops of first fluid in a second fluid intended to form the second phase; providing a second precursor polymer of the coacervate in the second fluid. ### Claim 9 (depends on 1) The method according to claim 1, including, during the solution injection, injecting a first solution increasing the viscosity, suitable for increasing the viscosity of the second phase, the method comprising, after recovering the dispersion: returning an intermediate dispersion, comprising a second phase with a partially increased viscosity, to circulation; injecting a second solution increasing the viscosity into the dispersion. ### Claim 10 (depends on 9) The method according to claim 9, wherein the recirculation includes the circulation of the dispersion in an additional duct, then the recovery of the dispersion in a container at the outlet of the additional duct, the injection of the second solution increasing the viscosity being done in the additional duct, or at the outlet of the additional duct, upstream from the container. ### Claim 11 (depends on 1) The method according to claim 1, wherein the solution for increasing the viscosity contains a base. ### Claim 12 (depends on 1) The method according to claim 1, injecting the solution increasing the viscosity includes bringing at least part of the solution increasing the viscosity to the center of the circulation duct, the drops flowing in a central passage defined by the crown and in a peripheral passage defined between the crown and the circulation duct.