Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
AssigneeGlobeImmune, Inc.
InventorsThomas H. King, David Apelian
Life of this patent
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Abstract
Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods of use of such compositions to prevent and/or treat HDV infection and symptoms and sequela thereof.
Claims20
A method of inducing a hepatitis D Virus (HDV)-specific immune response in a subject who is infected with HDV, comprising administering to a subject that has been infected with HDV at least one immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein having an amino acid sequence selected from SEQ ID NO:
- 36 or SEQ ID NO:30 or an amino acid sequence that is at least 99% identical to SEQ ID ID:36 or SEQ ID NO:30, respectively;
- wherein the composition elicits an HDV-specific immune response when administered to the subject.
A method to elicit an antigen-specific, cell-mediated immune response against an HDV antigen, comprising administering to a subject at least one composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein having an amino acid sequence selected from SEQ ID NO:
- 36 or SEQ ID NO:30 or an amino acid sequence that is at least 99% identical to SEQ ID NO:36 or SEQ ID NO:30, respectively;
- wherein the composition elicits an HDV-specific immune response when administered to the subject.
Dependencies are inferred from the claim text.