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AssigneeSENTINEXT THERAPEUTICS Sdn Bhd
InventorsMary Jane Cardosa, Mohamad Fakruddin Jamiluddin, Sharifah Binti Hamid
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The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enterovirus A, Human Enterovirus B, Human enterovirus C, Human Enterovirus D antigens and their use in vaccines for the prevention of an enterovirus infection.
A vaccine comprising a human Enterovirus A virus-like particle, the virus-like particle comprising human Enterovirus A VP0 polypeptides, human Enterovirus A VP1 polypeptides, human Enterovirus A VP2 polypeptides, human Enterovirus A VP3 polypeptides and human Enterovirus A VP4polypeptides, wherein the vaccine elicits an immune response and/or neutralizing antibody response directed against the human Enterovirus A.
Dependencies are inferred from the claim text.