Compositions comprising bacterial strains
Assignee4D Pharma Research Limited
InventorsImke Elisabeth Mulder, Amy Beth Holt, Seanin Marie McCluskey, Grainne Clare Lennon, Suaad Ahmed
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Abstract
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
Claims23
A pharmaceutical composition that reduces inflammation associated with Th17 differentiation in a subject in need thereof, that comprises a therapeutically effective amount of a single bacteria strain of the species Erysipelatoclostridium ramosum;
- and
- a pharmaceutically acceptable excipient, diluent, or carrier;
- wherein the therapeutically effective amount comprises from about 1×103 to about 1×1011 CFU of the bacteria strain;
- wherein the bacterial strain is lyophilized;
- and
- wherein the bacteria strain comprises a polynucleotide sequence of a 16s rRNA gene that has at least 95% sequence identity to the polynucleotide sequence of SEQ ID NO:3, as determined by a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12, a gap extension penalty of 2, and a Blocks Substitution Matrix (BLOSUM) of 62.
A method of treating a condition in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition that comprises a bacteria strain of the species Erysipelatoclostridium ramosum and a pharmaceutically acceptable excipient, diluent, or carrier;
- wherein the bacteria strain is present in an amount sufficient for treating a condition mediated by the Th17 pathway or by an increase in the IL-17 cytokine in the subject;
- wherein the therapeutically effective amount comprises from about 1×103 to about 1×1011 CFU of the bacteria strain;
- wherein the bacteria strain is lyophilized;
- and
- wherein the bacteria strain comprises a polynucleotide sequence of a 16s rRNA gene that has at least 95% identity to the polynucleotide sequence of SEQ ID NO:3, as determined by a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12, a gap extension penalty of 2, and a Blocks Substitution Matrix (BLOSUM) of 62.
Dependencies are inferred from the claim text.