Method for producing regenerative organ primordium provided with guide for transplantation, composition containing regenerative organ primordium provided with guide for transplantation produced thereby, and method for transplanting regenerative organ primordium provided with guide for transplantation

A method for producing a regenerative hair follicle germ having a guide for transplantation, comprising:

• preparing a regenerative hair follicle germ by closely contacting a first cell mass substantially consisting of mesenchymal cells and a second cell mass substantially consisting of epithelial cells and culturing the first cell mass and the second cell mass within a gel or liquid support carrier that is made of collagen, agarose gel, carboxymethyl cellulose, gelatin, agar, hydrogel, elastin, fibrin, or laminin;
• inserting the guide into the regenerative hair follicle germ,
• wherein the guide is maintained in a state in which the guide protrudes from the regenerative hair follicle germ before implantation,
• wherein the guide is consisting essentially of a fiber selected from the group consisting of a fiber made from a polymer, a metallic fiber, a carbon fiber, a chemical fiber, and a natural animal or plant fiber, and
• wherein a part of the guide is surrounded by the regenerative hair follicle germ;
• and
• culturing the regenerative hair follicle germ before implantation.