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US 9,982,042 B2Granted
Therapeutic combination and methods of treatment with a DLL4 antagonist and an anti-hypertensive agent
AssigneeOncoMed Pharmaceuticals, Inc.
InventorsRobert Joseph Stagg, Steven Eugene Benner
Life of this patent
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Abstract
Methods for treating cancer comprising administering a DLL4 antagonist and one or more anti-hypertensive agents are described. Also described are pharmaceutical compositions comprising a DLL4 antagonist and one or more anti-hypertensive agents, and kits comprising the same.
Claims51
A method of ameliorating hypertension in a subject receiving treatment with a delta-like ligand 4 (DLL4) antagonist, the method comprising:
- administering to the subject a therapeutically effective amount of one or more anti-hypertensive agents to control hypertension caused by the antagonist,
- wherein the DLL4 antagonist comprises a monoclonal antibody that specifically binds human DLL4.
A method of detecting and ameliorating hypertension in a subject receiving treatment with a delta-like ligand 4 (DLL4) antagonist, the method comprising:
- (a) measuring the blood pressure of the subject after receiving treatment with the DLL4 antagonist;
- and
- (b) administering to the subject a therapeutically effective amount of one or more anti-hypertensive agents to control hypertension caused by the antagonist,
- wherein the DLL4 antagonist comprises a monoclonal antibody that specifically binds human DLL4.
1 more element
Dependencies are inferred from the claim text.