Chemical reagents for attaching affinity molecules on surfaces
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsPeiming Zhang, Subhadip Senapati, Saikat Manna
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Abstract
Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments of the present disclosure may be incorporated into or operatively-linked with affinity molecules for attachment to silicon oxide surfaces to, for example, measure interactions between an affinity molecule and its targeting biomolecules.
Claims20
A compound of Formula I:
- wherein:
- X is O, CH2, NH or NCH3;
- Y is O, CH2, NH or NCH3;
- P is CH2 or O;
- and
- s and t are each independently 0, 1, 2, 3, 4, or 5.
A compound of Formula III:
- wherein:
- A is CH2 or O;
- and
- u is any integer ranging from 1 to 36.
A composition comprising
A method for preparing a compound according to Formula I, comprising contacting a silatrane to a functionalized acid in the presence of a coupling reagent.
A method of preparing compound 6a, comprising:
- a. mixing hexatheylene glycol and
- in the presence of a first base to form
- and
- b. mixing divinyl sulfone,
- and a second base, to form
Dependencies are inferred from the claim text.