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US 9,981,894 B2Granted
Intermediate compounds for producing perfuming ingredients
AssigneeFirmenich SA
InventorsMurielle Haldimann Sanchez, Philippe Dupau
Life of this patent
Estimating the term…
Abstract
The present invention relates to the field of chemical processes and, more particularly, it concerns valuable new chemical intermediates of formula (IV) for producing perfuming ingredients.
Claims15
A process for the preparation of a compound of formula
- in the form of any one of its stereoisomers or a mixture thereof, and wherein each R1, R2, R3 and R4, independently from each other, represents a hydrogen atom or a C1-3 alkyl group;
- characterized in that said process comprises the steps of:
- a) reducing a precursor compound of the formula
- in the form of any one of its stereoisomers or a mixture thereof, and wherein each R1, R2, R3 and R4, is defined as in formula (I);
- and
- A represents a C3-10 trialkylsilyl or an RCO group wherein R represents a hydrogen atom, a C1-8 alkyl group, or a phenyl optionally substituted by one to three groups selected amongst a C1-3 alkyl, alkoxy or amine group;
- into an indane of formula
- in the form of any one of its stereoisomers or a mixture thereof, and wherein each R1, R2, R3, R4 and A is defined as in formula (II);
- and
- b) hydrolysing the indane of formula (III) into the compound of formula (I).
7 more elements
A compound of formula
- in the form of any one of its stereoisomers or a mixture thereof, and wherein X represents a CH2 or C═O group;
- each R1, R2, R3, and R4 independently from each other, represents a hydrogen atom or a C1-3 alkyl group;
- and A represents a C3-10 trialkylsilyl or an RCO group wherein R represents a hydrogen atom, a C1-8 alkyl group, or a phenyl optionally substituted by one to three groups selected amongst a C1-3 alkyl, alkoxy or amine group, provided that (2-methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl acetate, (2-methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl formate, (2-methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl benzoate, ((2-methyl-2,3-dihydro-1H-inden-2-yl)methyl acetate, (6-methyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl acetate and (5-ethyl-2-methyl-2,3-dihydro-1H-inden-2-yl)methyl acetate are excluded.
Dependencies are inferred from the claim text.