Compositions, comprising improved Il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid B. Weiner, Matthew P. Morrow, Jian Yan
Life of this patent
Estimating the term…
Abstract
Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL 12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.
Claims15
A composition for modulating an immune system that comprises a) a nucleic acid sequence that encodes an IL-12 p35 subunit and b) a nucleic acid sequence that encodes an IL-12 p40 subunit, wherein
- the nucleic acid sequence that encodes the IL-12 p35 subunit is at least 95% identical to SEQ ID NO:1 and encodes a protein at least 95% identical to SEQ ID NO:2, and
- the nucleic acid sequence that encodes the IL-12 p40 subunit is at least 95% identical to SEQ ID NO:3 and encodes a protein at least 95% identical to SEQ ID NO:4.
Dependencies are inferred from the claim text.