Targeted self-assembly of functionalized carbon nanotubes on tumors

A method for delivering a therapeutic radionuclide in situ to a cancer cell of interest in a subject, comprising:

• contacting the cancer cell with a first component comprising a morpholino oligonucleotide consisting of SEQ ID NO:
• 1 linked to an antibody selective for the cancer cell;
• contacting the first component with a second component comprising a soluble single wall nanotube construct having:
• a plurality of morpholino oligonucleotides each consisting of SEQ ID NO:
• 2 complementary to the morpholino oligonucleotide sequence consisting of SEQ ID NO:
• 1 in the first component;
• and
• a plurality of the therapeutic radionuclide each independently linked to the single wall nanotube via a bifunctional chelator;
• said first component hybridizing to the second component upon contact therewith to form a self-assembled soluble single wall nanotube complex at the cancer cell, wherein the self-assembled soluble single wall nanotube complex is capped and internalized, thereby delivering in situ the therapeutic radionuclide to the cancer cell of interest in the subject.