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US 9,975,823 B2Granted
Process for the preparation of 5-bromo-1,2,3-trichlorobenzene
AssigneeSyngenta Participations AG
InventorHelmars Smits
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Abstract
The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacting the compound of formula III in tetrahydrofuran or 2-methyl-tetrahydrofuran with potassium tert-butoxide to a compound of formula I.
Claims4
A process for the preparation of a compound of formula I
- comprising
- a) reacting a compound of formula II
- with a brominating agent in the presence of an acidic catalyst to a compound of formula III,
- and, wherein the acidic catalyst is sulfuric acid, hydrochloric acid, phosphoric acid, Lewis acids or acidic catalyst prepared in situ by mixing bromine with iron powder;
- and wherein the brominating agent is bromine or N-bromo succinimide;
- b) reacting the compound of formula III in tetrahydrofuran or 2-methyl-tetrahydrofuran with potassium tert-butoxide to form a compound of formula I.
3 more elements
Dependencies are inferred from the claim text.