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US 9,974,815 B2Granted
Compositions comprising bacterial strains
Assignee4D Pharma Research Limited
InventorsImke Elisabeth Mulder, Amy Beth Holt, Domenico Panzica, Seanin Marie McClusky
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Abstract
The invention provides compositions comprising bacterial strains for treating and preventing cancer.
Claims10
A method of treatment of cancer in a subject in need thereof, comprising:
- administering to the subject a therapeutically effective amount of a pharmaceutical composition that comprises:
- a bacteria strain with a 16s rRNA gene sequence with at least 99.5% sequence identity to the polynucleotide of SEQ ID NO:2, wherein the sequence identity is determined by the Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12 and a gap extension penalty of 2, and a BLOSUM matrix of 62;
- wherein said bacteria strain has a carbohydrate fermentation profile that comprises:
- (i) a positive fermentation of at least one of:
- L-arabinose and D-xylose;
- and (ii) an intermediate fermentation of Methyl-αD-glycopyranoside;
- wherein said bacteria strain is present in an amount sufficient for treatment of cancer in the subject, and wherein the cancer is a solid tumor cancer.
4 more elements
Dependencies are inferred from the claim text.