Fumagillol derivatives and polymorphs thereof
AssigneeSynDevRx, Inc.
InventorJohn S. Petersen
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to salts and polymorphs of aminoalkylfumagillol carbamates (e.g., fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate benzenesulfonic acid salt and fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate hydroxynaphthoic acid salt). The polymorphs are characterized by X-ray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis, among other methods. The polymorphs and salts can be used as intermediates in the production of fumagillol derivatives (e.g., polymer-conjugated fumagillol derivatives) as well as therapeutic agents for the treatment of various diseases and conditions such as cancer.
Claims18
A polymorphic form of fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate benzenesulfonic acid salt, characterized by an X-ray powder diffraction pattern including peaks at 6.0, 9.0, 12.3, 12.5, 16.1, and 18.0 °2θ using Cu Kα radiation.
Dependencies are inferred from the claim text.