Methods and apparatus for kidney dialysis and extracorporeal detoxification
AssigneeNephroGenesis LLC
InventorJames A. Tumlin
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Abstract
The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.
Claims27
An apparatus for a dialysis procedure comprising a body having an inlet and an outlet and defining an interior, the interior including at least one membrane having at least one protein from the lipocalin family bound thereon, wherein the apparatus is arranged so that a fluid entering the apparatus contacts the at least one protein from the lipocalin family bound to the at least one membrane in the interior of the apparatus, wherein the at least one protein from the lipocalin family comprises at least one olfactory binding protein.
A method of dialysis comprising subjecting a bodily fluid from a subject to an apparatus comprising a body having an inlet and an outlet and defining an interior, the interior including at least one membrane having at least one protein from the lipocalin family bound thereon, wherein the apparatus is arranged so that the bodily fluid entering the apparatus contacts the at least one protein from the lipocalin family bound to the at least one membrane in the interior of the apparatus, wherein the at least one protein from the lipocalin family comprises at least one olfactory binding protein.
A method of preventing or treating uremia comprising subjecting a bodily fluid from a subject to an apparatus comprising a body having an inlet and an outlet and defining an interior, the interior including at least one membrane having at least one protein from the lipocalin family bound thereon, wherein the apparatus is arranged so that the bodily fluid entering the apparatus contacts the at least one protein from the lipocalin family bound to the at least one membrane in the interior of the apparatus, wherein the at least one protein from the lipocalin family comprises at least one olfactory binding protein.
A method of dialysis comprising:
- (a) providing a solution comprising at least one protein from the lipocalin family to the interior of a dialysis apparatus;
- and
- (b) subjecting a bodily fluid from a subject to the dialysis apparatus comprising a body having an inlet and an outlet and defining an interior, wherein the interior includes at least one membrane capable of binding the at least one protein from the lipocalin family and the dialysis apparatus is arranged so that the bodily fluid entering the dialysis apparatus contacts the at least one protein from the lipocalin family bound to the least one membrane in the interior of the apparatus, wherein the least one protein from the lipocalin family comprises at least one olfactory binding protein, and wherein clearance of hydrophobic , protein bound uremic toxins is facilitated.
A method of extracorporeal detoxification comprising subjecting a bodily fluid from a subject to an apparatus comprising a body having an inlet and an outlet and defining an interior, wherein the interior includes at least one membrane capable of binding the at least one protein from the lipocalin family and the apparatus is arranged so that the bodily fluid entering the apparatus contacts the at least one protein from the lipocalin family bound to the at least one membrane in the interior of the apparatus, wherein the at least one protein from the lipocalin family comprises at least one olfactory binding protein, wherein clearance of a drug is facilitated.
Dependencies are inferred from the claim text.