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US 9,968,706 B2Granted
Nerve regeneration employing keratin biomaterials
AssigneeWake Forest University Health Sciences
InventorMark E. Van Dyke
Life of this patent
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Abstract
A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
Claims11
A device for promoting the growth of a nerve in a mammal, comprising:
- a support structure having an elongate opening formed therein and configured for placement around a damaged region of a nerve;
- and
- a physiologically acceptable matrix composition in said opening, said matrix composition comprising soluble keratose, soluble kerateine, or a mixture thereof,
- wherein said soluble keratose is produced by a process of separating soluble keratose from oxidized hair using an aqueous solution comprising a denaturing agent, and
- wherein said soluble kerateine is produced by a process of separating soluble kerateine from reduced hair using an aqueous solution comprising a denaturing agent.
2 more elements
A kit comprising:
- (a) a support structure having an elongate opening formed therein and configured for placement around a damaged region of a nerve;
- (b) a container, wherein said support structure is packaged in said container sterile form;
- and
- (c) a physiologically acceptable matrix composition, wherein said matrix composition is sterile, and wherein said matrix composition comprises soluble keratose, soluble kerateine, or a mixture thereof,
- wherein said soluble keratose is produced by a process of separating soluble keratose from oxidized hair using an aqueous solution comprising a denaturing agent, and
- wherein said soluble kerateine is produced by a process of separating soluble kerateine from reduced hair using an aqueous solution comprising a denaturing agent.
3 more elements
Dependencies are inferred from the claim text.