Back to results
US 9,968,652 B2Granted
Optically-controlled CNS dysfunction
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKarl Deisseroth, Kay Tye, Lief Fenno
Life of this patent
Estimating the term…
Abstract
Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
Claims12
A system comprising:
- a) a non-human animal comprising a light-responsive opsin expressed in glutamatergic pyramidal neurons of the basolateral amygdala (BLA), wherein the opsin is an opsin which induces hyperpolarization of a neuron in response to light, and wherein the selective illumination of the opsin in the BLA-CeL induces anxiety of the animal;
- b) a beveled guide cannula configured to be placed over the CeL to prevent light delivery to the BLA and to allow selective illumination of the CeA;
- and
- c) a light source.
1 more element
Dependencies are inferred from the claim text.