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US 9,968,571 B2Granted
Inhibitors and methods of inhibiting bacterial and viral pathogens
AssigneeSiga Technologies, Inc.
InventorsRobert D. Allen, III, Sean M. Amberg, Dongcheng Dai, James R. Burgeson, Dennis E. Hruby
Life of this patent
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Abstract
Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
Claims12
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the following general Formula I or a pharmaceutically acceptable salt thereof:
- wherein R1 is selected from the group consisting of:
- H, chloro, methyl, methoxy, ethoxy, nitro and fluoro;
- R2 is selected from the group consisting of:
- H, chloro, methyl, methoxy, trifluoromethyl, propanoylamino and 2-methylpropanoylamino;
- R3 is selected from the group consisting of:
- H, methyl, amino, methylamino, dimethylamino, phenylamino and 3-pyridylamino;
- R4 is selected from the group consisting of:
- H, chloro, methyl, methoxy, trifluoromethyl and trifluoromethoxy;
- and
- R5 is selected from the group consisting of H and methyl;
- provided that R1, R2, R3, R4, and R5 cannot all be H;
- and
- provided that when R3 is amino, then R1, R2, R4, and R5 cannot all be H.
10 more elements
Dependencies are inferred from the claim text.