Immunomodulatory properties of multipotent adult progenitor cells and uses thereof

A method of adjunctive treatment of an immune dysfunction characterized by adverse T-cell activation or proliferation in a subject, comprising:

• administering to a subject in need of treatment for adverse T-cell activation or proliferation associated with an immune dysfunction, by an effective route and in an effective amount to treat the adverse T-cell activation or proliferation cells that:
• are not embryonic stem cells, embryonic germ cells, or germ cells, express telomerase, have undergone at least 10-40 cell doublings in culture, have a normal karyotype, are allogeneic to the subject, do not provoke a deleterious immune response in the subject, and are effective to treat the adverse T-cell activation or proliferation in the subject, wherein the cells are administered adjunctively to one or more other treatments administered to the subject, and wherein the cells have not been genetically engineered to improve their immunological properties, wherein the immune dysfunction is not GVHD and is not diabetes.