OxMIF as a diagnostic marker

A method for in vitro diagnosis of a disease related to the presence of oxMIF in a subject, said method comprising:

• a) contacting a sample from said subject with an anti-oxMIF antibody wherein said antibody binds oxMIF but not redMIF;
• wherein said antibody is selected from the group consisting of:
• i. a RAB4 antibody, characterized by a light chain sequence as deposited by way of plasmid deposition with deposit number DSM 25110 and a heavy chain sequence as deposited by way of plasmid deposition with deposit number DSM 25112,
• ii. a RAB9 antibody, characterized by a light chain sequence as deposited by way of plasmid deposition with deposit number DSM 25111 and a heavy chain sequence as deposited by way of plasmid deposition with deposit number DSM 25113,
• iii. a RAB0 antibody, characterized by a light chain sequence as deposited by way of plasmid deposition with deposit number DSM 25114 and a heavy chain sequence as deposited by way of plasmid deposition with deposit number DSM 25115,
• iv. a RAB4 antibody, which is characterized by a light chain amino acid sequence of SEQ ID NO:
• 2 and a heavy chain amino acid sequence of SEQ ID NO:6,
• v. a RAB9 antibody, which is characterized by a light chain amino acid sequence of SEQ ID NO:
• 1 and a heavy chain amino acid sequence of SEQ ID NO:5,
• vi. a RAB0 antibody, which is characterized by a light chain amino acid sequence of SEQ ID NO:
• 3 and a heavy chain amino acid sequence of SEQ ID NO:7, and
• b) detecting the presence of oxMIF in said sample by detecting the binding of said anti-oxMIF antibody to said sample, wherein binding of said anti-oxMIF antibody to said sample is indicative of the presence of oxMIF in said sample, and wherein the presence of a higher level of oxMIF in said sample as compared to the level of oxMIF in a healthy control is indicative of the presence of a MIF-related disease in said sample.