Apparatus, systems and methods for sensing an analyte such as ethanol

An apparatus for sensing an analyte, comprising:

• a substrate having a first rigid region and a first trench region, the first trench region being thinner than the first rigid region;
• and
• a sensor block supported by the first rigid region, the sensor block comprising:
• a frame layer extending upwardly from the first rigid region, the frame layer having a first end opposite the substrate to engage with a tissue sample, the frame layer having an opening therein extending between the substrate and the first end defining a pocket;
• and
• a sensor located within the pocket distal the first end, the sensor comprising:
• a first substance having a property adapted to change in response to the presence of the analyte;
• and
• a resonant element covered by the first substance and operable to detect the change in the property of the first substance;
• wherein the first trench region is laterally positioned relative to the first rigid region and the sensor block to provide for flexed deformation of the substrate within the first trench region upon flexing the substrate.