Back to results
US 9,958,432 B2Granted
Cellular cis-co-culture systems for analysis
AssigneeLynx Biosciences, Inc.
InventorsChorom Pak, Edmond Wai Keung Young, Natalie Callander, David James Beebe, Shigeki Miyamoto
Life of this patent
Estimating the term…
Abstract
The invention relates to systems and methods for studying patient cancer samples in cis-co-culture with stromal cells from the same patient. For example, the invention provide systems and methods for testing therapeutic agents in vitro in an environment that simulates an in vivo environment to identify agents that are therapeutically effective for the patient.
Claims21
A method for cellular analysis comprising:
- (a) placing hematological cancer cells isolated from a patient on a solid support;
- (b) placing non-cancerous mononuclear cells comprising bone marrow stromal cells isolated from the same patient in a different region of said solid support and in fluidic connection with the cancer cells;
- (c) contacting the cancer cells and/or non-cancerous cells with an agent;
- and
- (d) measuring an effect or lack of effect of the agent on the cancer cells and/or non-cancerous
- wherein the cellular analysis is completed within four days of isolation of both the cancer cells and the non-cancerous cells from the patient.
3 more elements
Dependencies are inferred from the claim text.