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US 9,958,414 B2Granted
Apparatus for measuring analytes including chemical sensor array
AssigneeLife Technologies Corporation
InventorsJonathan Rothberg, Todd Rearick
Life of this patent
Estimating the term…
Abstract
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
Claims7
A system having an array, comprising:
- a plurality of chemical sensors configured to detect a quantity of a substance;
- a selection circuit arranged to select a subset of the chemical sensors for a time period during which the subset of chemical sensors will provide an output signal, wherein the time period is shorter than an amount of time required for the output signal from the chemical sensors to settle and reach their final value from detecting the quantity of the substance;
- a plurality of output circuits configured to receive the output signals from the subsets of the chemical sensors during the time period;
- a sampling circuit configured to take a plurality of samples from each of the output signals during the time period;
- and
- an estimator that receives the plurality of samples and generates an estimated value for each of the sensors during the time period.
3 more elements
Dependencies are inferred from the claim text.