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US 9,957,576 B2Granted
Methods for determining responsiveness to an anti-CD47 agent
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsIrving L. Weissman, Victor Albert Eng, Rahul Sinha
Life of this patent
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Abstract
Methods and kits are provided for determining whether an individual is responsive to an anti-CD47 agent by assaying biological samples for the level or ratio of isoforms of CD47 in the sample.
Claims6
A method of treating an individual responsive to an anti-CD47 agent, the method comprising:
- assaying a cell sample from an individual to measure the levels of two or more CD47 isoforms,
- determining that the individual is responsive to the anti-CD47 agent when the level of a CD47 isoform comprising a cytoplasmic tail is present at a ratio of at least 1:10 relative to other CD47 isoforms, and
- administering an anti-CD47 agent to the responsive individual.
Dependencies are inferred from the claim text.