Method for detecting polymorphisms

A method of detecting polymorphisms in a biological sample, comprising

• (a1) assaying the biological sample isolated from a human subject for the presence of polymorphisms at position 27 within each of the nucleic acid sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:10 by direct sequencing of nucleic acids in the sample;
• or
• (a2) assaying the biological sample isolated from a human subject for the presence of polymorphisms at position 27 within each of the nucleic acid sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:10 by detecting hybridization or lack of hybridization of the nucleic acid sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:10 in the biological sample with the set of nucleic acid probes;
• and
• (b) detecting polymorphisms in the biological sample at position 27 within the nucleic acid sequences of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:10 based on the sequencing in (a1) or detecting hybridization or lack of hybridization in (a2);
• wherein the polymorphism at position 27 within the nucleic acid sequences of SEQ ID NOs:1, 3 and 7-10 is a C in SEQ ID NO:1, C in SEQ ID NO:3, T in SEQ ID NO:7, C in SEQ ID NO:8, C in SEQ ID NO:9, and T in SEQ ID NO:10.