Genetically engineered bacterium for the production of 3-hydroxybutyrate
AssigneeLanzatech New Zealand Limited
InventorsMichael Koepke, Rasmus Overgaard Jensen, James Bruce Yarnton Haycock Behrendorff, Ryan Edward Hill, Darmawi Juminaga, Alexander Paul Mueller
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Abstract
The invention relates to a genetically engineered bacterium having an enzyme that converts acetyl-CoA to acetoacetyl-CoA, an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and an enzyme that converts 3-hydroxybutyryl-CoA to 3-hydroxybutyrate. The bacterium may also have enzymes to produce other downstream products, such as 3-hydroxybutyryaldehyde, and 1,3-butanediol. Typically, the bacterium is capable of producing these products from a gaseous substrate, such as syngas or an industrial waste gas.
Claims20
A genetically engineered C1-fixing bacterium comprising:
- (a) an enzyme that converts acetyl-CoA to acetoacetyl-CoA,
- (b) an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and
- (c) an enzyme that converts 3-hydroxybutyryl-CoA to 3-hydroxybutyrate,
- wherein at least one of the enzymes is exogenous to the bacterium.
Dependencies are inferred from the claim text.