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US 9,957,512 B2Granted
Biological methods for preparing a fatty dicarboxylic acid
AssigneeVerdezyne, Inc.
InventorsTom Beardslee, Stephen Picataggio, Alex Hutagalung, Tom Fahland
Life of this patent
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Abstract
The technology relates in part to biological methods for producing a fatty dicarboxylic acid and engineered microorganisms capable of such production.
Claims17
A method for producing a diacid, comprising:
- contacting a genetically modified yeast with a feedstock capable of being converted by the yeast to a diacid;
- and
- culturing the yeast under conditions in which the diacid is produced from the feedstock,
- wherein the genetically modified yeast comprises an active, modified endogenous acyl-coA Oxidase polypeptide, wherein the acyl-coA Oxidase polypeptide comprises an amino acid sequence with modification at one or more amino acid positions chosen from residues 81, 82, 83, 84, 85, 86, 88, 93, 94, 95, 96, 98, 102, 284, 287, 290, 291, 292, 294, 295, 436, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, and 463 of SEQ ID NO:
- 32.
2 more elements
Dependencies are inferred from the claim text.