Compositions and methods for inhibiting expression of mutant EGFR gene

A double-stranded ribonucleic acid (dsRNA), wherein said dsRNA is 15-30 nucleotides in length and comprises at least two sequences that are complementary to each other,

• wherein a sense strand comprises a first sequence comprising a nucleotide sequence chosen from SEQ ID NO:
• 8, SEQ ID NO:
• 10, SEQ ID NO:
• 12, SEQ ID NO:
• 16, SEQ ID NO:
• 54, SEQ ID NO:
• 56, SEQ ID NO;
• 58, SEQ ID NO:
• 60, or SEQ ID NO:
• 64, and
• wherein an antisense strand comprises a second sequence comprising a region of complementarity which is substantially complementary to at least a part of the first sequence, wherein the second sequence comprises a nucleotide sequence chosen from SEQ ID NO:
• 9, SEQ ID NO:
• 11, SEQ ID NO:
• 13, SEQ ID NO:
• 17, SEQ ID NO:
• 55, SEQ ID NO:
• 57, SEQ ID NO;
• 59, SEQ ID NO:
• 61, or SEQ ID NO:
• 65, and wherein said region of complementarity is 15-30 nucleotides in length.