Fluorescent probe for imaging lymph nodes
AssigneeEisai R&D Management Co., Ltd.
InventorsHideki Hayashi, Masanori Fujinami, Taro Toyota, Yutaka Tamura, Akira Aoki, Yutaka Muraki, Kazuki Onoue
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Abstract
Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
Claims27
A fluorescent probe for near-infrared fluorescent imaging in sentinel lymphadenography comprising a liposome containing a fluorescent dye having a hexatriene skeletal structure, wherein the fluorescent dye having a hexatriene skeletal structure is a compound represented by chemical formula (V):
- wherein, n represents an integer of 4 to 18.
A near-infrared fluorescent imaging agent comprising a compound represented by chemical formula (V):
- wherein, n represents an integer of 4 to 18.
A compound represented by chemical formula (V):
- wherein, n represents an integer of 4 to 18.
Dependencies are inferred from the claim text.