Compositions and methods for treating cocaine-related disorders
AssigneeUniversity of Cincinnati
InventorsAndrew B. Norman, William J. Ball
Life of this patent
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Abstract
A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a murine lambda light chain. In a specific embodiment, the antibody is a monoclonal antibody comprising a murine lambda light chain variable region, a human gamma heavy chain variable region, and a human kappa or lambda light chain constant region.
Claims8
A monoclonal antibody that specifically binds cocaine, wherein said antibody comprises:
- (a) a murine lambda light chain variable region CDR1 comprising SEQ ID NO:
- 4;
- (b) a murine lambda light chain variable region CDR2 comprising SEQ ID NO:
- 5;
- (c) a murine lambda light chain variable region CDR3 comprising SEQ ID NO:
- 6;
- (d) a human gamma heavy chain variable region CDR1 comprising SEQ ID NO:
- 7;
- (e) a human gamma heavy chain variable region CDR2 comprising SEQ ID NO:
- 8;
- (f) a human gamma heavy chain variable region CDR3 comprising SEQ ID NO:
- 9;
- and
- (g) a human light chain constant region.
A method of treating a cocaine-related disorder in an individual, comprising administering to the individual a therapeutic amount of a monoclonal antibody that specifically binds cocaine, wherein the antibody comprises:
- (a) a murine lambda light chain variable region CDR1 comprising SEQ ID NO:
- 4;
- (b) a murine lambda light chain variable region CDR2 comprising SEQ ID NO:
- 5;
- (c) a murine lambda light chain variable region CDR3 comprising SEQ ID NO:
- 6;
- (d) a human gamma heavy chain variable region CDR1 comprising SEQ ID NO:
- 7;
- (e) a human gamma heavy chain variable region CDR2 comprising SEQ ID NO:
- 8;
- (f) a human gamma heavy chain variable region CDR3 comprising SEQ ID NO:
- 9;
- and
- (g) a human light chain constant region.
Dependencies are inferred from the claim text.