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US 9,957,330 B2Granted
Polypeptides
AssigneeAffibody AB
InventorsLars Abrahmsén, Ingmarie Höidén-Guthenberg, Elin Gunneriusson
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Abstract
The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX (CAIX), and provides a CAIX binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10X11LPN LX16X17X18QX20 X21AFIX25X26LWD. The present disclosure also relates to the use of such a CAIX binding polypeptide as a diagnostic, prognostic agent and/or therapeutic agent.
Claims19
A CAIX binding polypeptide, comprising a CAIX binding motif BM, which motif consists of the amino acid sequence:
- i)
- (SEQ ID NO:
- 369)
- EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LWD
- wherein, independently from each other,
- X2 is selected from D, H, N, Q and W;
- X3 is selected from I, L, Q, R, and W;
- X4 is selected from A, F, W and Y;
- X6 is selected from A, G and S;
- X7 is selected from G, I, V and W;
- X10 is selected from A, D, E, G, N, Q, R, S and T;
- X11 is selected from D, E and S;
- X16 is selected from N and T;
- X17 is selected from A, D, E, I, Q, T and V;
- X18 is selected from A, D, E, F, G, H, N, Q, R, S and Y;
- X20 is R;
- X21 is selected from D, H and N;
- X25 is Y;
- X26 is selected from K and S.
16 more elements
Dependencies are inferred from the claim text.