Antibodies that bind colony stimulating factor 1 receptor (CSF1R)
AssigneeFive Prime Therapeutics, Inc.
InventorsJustin Wong, Maximiliano Vasquez
Life of this patent
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Abstract
Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis, bone loss, and multiple sclerosis.
Claims24
An isolated antibody comprising a heavy chain comprising a heavy chain (HC) CDR1 having the sequence of SEQ ID NO:15, an HC CDR2 having the sequence of SEQ ID NO:16, and an HC CDR3 having the sequence of SEQ ID NO:17;
- and comprising a light chain comprising a light chain (LC) CDR1 having the sequence of SEQ ID NO:18, a LC CDR2 having the sequence of SEQ ID NO:19, and a LC CDR3 having the sequence of SEQ ID NO:20, wherein the antibody binds to human colony stimulating factor 1 receptor (CSF1R).
An isolated antibody comprising a heavy chain comprising the sequence of SEQ ID NO:39 and a light chain comprising the sequence of SEQ ID NO:46, wherein the antibody binds to human CSF1R.
An isolated antibody comprising a heavy chain comprising the sequence of SEQ ID NO:53 and a light chain comprising the sequence of SEQ ID NO:60, wherein the antibody binds to human CSF1R.
An isolated antibody comprising a heavy chain consisting of the sequence of SEQ ID NO:53 and a light chain consisting of the sequence of SEQ ID NO:60, wherein the antibody binds to human CSF1R.
Dependencies are inferred from the claim text.