FGFR-FC fusion proteins and the use thereof

An isolated soluble fusion protein which binds fibroblast growth factor (FGF), comprising a region derived from the extracellular domain of FGFR and an immunoglobulin Fc region, said isolated soluble fusion protein contains no acidic box, which is set forth in amino acid residues 126 to 133 of SEQ ID NO:1, and said region derived from the extracellular domain of FGFR consists of:

• a part derived from an intermediate functional sequence (IFS) of an Ig-like domain of FGFR, a second Ig-like domain (D2) of FGFR, and a third Ig-like domain (D3) of FGFR,
• wherein the sequence of the part derived from the IFS is a sequence of amino acid residues corresponding to position 142 to 162, 143 to 162, 144 to 162, 145 to 162, 146 to 162, 147 to 162, or 148 to 162 of SEQ ID NO:
• 1;
• D2 has a sequence of amino acid residues corresponding to position 163 to position 247 of SEQ ID NO:
• 1;
• D3 has a sequence of amino acid residues corresponding to position 270 to position 359 of SEQ ID NO:
• 1;
• and
• the part derived from IFS, D2, D3 and the immunoglobulin Fc region are linked directly or by a linker.