Surface-binding peptide
AssigneeTikomed AB
InventorsLars Bruce, Staale Lyngstadaas
Life of this patent
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Abstract
Surface-binding peptides have the capability of binding to surfaces of biocompatible materials and can thereby be used to immobilize various heterologous molecules of interest onto the surface. This means that surfaces of, for instance, implants and implantable medical devices can be tailored to present various characteristics by immobilizing selected heterologous molecules of interest on the surfaces of the implants and implantable medical devices. The surface-binding peptides consist of 5-17 consecutive amino acids of an extended beta-hairpin motif EIIATMKKKGEKRCLNP (SEQ ID NO: 57) in Interferon gamma-induced protein 10 (IP-10).
Claims22
An isolated combined surface-binding peptide consisting of at least two surface-binding peptides, wherein each of said at least two surface-binding peptides consists of N consecutive amino acids of an extended beta-hairpin motif EIIATMKKKGEKRCLNP (SEQ ID NO:
- 57) in interferon gamma-induced protein 10 (IP-10), wherein N=5-17, with the provisos that none of said surface-binding peptides are GEKRCL (SEQ ID NO:
- 65), and the sequence of said combined surface-binding peptide is different from any consecutive amino acid sequence portion of IP-10.
An artificial surface comprising a surface of a biocompatible material to which a surface-binding peptide is bound, wherein said surface-binding peptide consists of N consecutive amino acids of an extended beta-hairpin motif EIIATMKKKGEKRCLNP (SEQ ID NO:
- 57) in interferon gamma-induced protein 10 (IP-10), wherein N=5-17, with the proviso that said isolated surface-binding peptide is not GEKRCL (SEQ ID NO:
- 65).
A method of producing an artificial surface comprising binding a surface-binding peptide to a surface of a biocompatible material, wherein said surface-binding peptide consists of N consecutive amino acids of an extended beta-hairpin motif EIIATMKKKGEKRCLNP (SEQ ID NO:
- 57) in interferon gamma-induced protein 10 (IP-10), wherein N=5-17, with the proviso that said isolated surface-binding peptide is not GEKRCL (SEQ ID NO:
- 65).
Dependencies are inferred from the claim text.