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US 9,957,306 B2Granted
Hypoallergenic variants of mal d 1, the major allergen from malus domestica
AssigneeLofarma S.P.A.
InventorsGiovanni Mistrello, Stefania Zanotta, Daniela Roncarolo
Life of this patent
Estimating the term…
Abstract
Disclosed are hypoallergenic variants of Mal d 1, the major allergen from Malus domestica, and the uses thereof in the treatment of allergic diseases.
Claims1
A sequence variant of the Malus domestica major allergen, Mal d 1, said sequence variant showing reduced IgE reactivity relative to a wild-type Mal d 1 allergen, wherein said sequence variant is characterized by two alanine substitutions at positions 25 and 78 and otherwise having the sequence set forth in SEQ ID NO:1.
Dependencies are inferred from the claim text.