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US 9,957,305 B2Granted
Anti-C. difficile toxin antibodies and associated methods
AssigneeThe Board of Regents of the University of Oklahoma
InventorsJimmy D. Ballard, Jordi M. Melton, Latisha Heinlen, Elaine E. Hamm
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Abstract
Embodiments of the invention are directed to a composition comprising a recombinant protein in soluble form wherein said recombinant protein comprises a portion of the Clostridium difficile toxin B sequence that comprises an epitope for anti-toxin B antibody. Other embodiments of the invention are directed to the generation of antibodies using peptide fragments of C. difficile toxin B.
Claims1
A method of generating a neutralizing antitoxin directed against Clostridium difficile toxin B comprising:
- a) providing:
- i) a purified recombinant protein comprising a portion of the Clostridium difficile toxin B protein, wherein the portion of toxin B protein is selected from the group consisting of SEQ ID NO:
- 3, and wherein said recombinant protein is expressed in soluble form, and ii) a host;
- and b) immunizing said host with said recombinant protein in an amount sufficient to generate an antitoxin effective in neutralizing Clostridium difficile toxin B in vivo.
1 more element
Dependencies are inferred from the claim text.