Treating cancer with viral nucleic acid
AssigneeMayo Foundation for Medical Education and Research
InventorsStephen James Russell, Elizabeth J. Kelly, Elizabeth M. Hadac
Life of this patent
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Abstract
This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
Claims4
A method for treating cancer present in a mammal, wherein said method comprises intratumorally administering, to said mammal, an effective amount of viral nucleic acid coding for a picornavirus in the absence of (a) picornavirus particles and (b) host cells comprising said viral nucleic acid, wherein cancer cells present within said mammal undergo cell lysis as a result of synthesis of picornavirus particles from said viral nucleic acid, wherein said synthesis of picornavirus particles progresses into a picornavirus infection within said mammal, wherein said effective amount is between about 3×1010 and about 3×1014 virus genome copies, thereby reducing the number of viable cancer cells present within said mammal.
Dependencies are inferred from the claim text.