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US 9,957,298 B2Granted
Peptides as oxytocin agonists
AssigneeHoffmann-La Roche Inc.
InventorsCaterina Bissantz, Konrad Bleicher, Christophe Grundschober
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Abstract
The present compounds compounds are oxytocin receptor agonists for the treatment of autism, stress, including post traumatic stress disorder, anxiety, including anxiety disorders and depression, schizophrenia, psychiatric disorders and memory loss, alcohol withdrawal, drug addiction and for the treatment of Prader-Willi Syndrome.
Claims8
A compound of formula
- wherein
- R1 is methyl or cyclopropyl;
- R2 is hydrogen;
- R3 is hydrogen, lower alkyl, lower alkyl substituted by hydroxy, —(CH2)2C(O)NH2, benzyl, phenyl, —CH2-five membered aromatic heterocyclic group, CH2-indolyl, —CH2-cycloalkyl, cycloalkyl or —(CH2)2—S-lower alkyl;
- R3′ is hydrogen or lower alkyl;
- or
- X is —C(O)—CHR4—CHR4′—C(O)—NH—CH2—
- R4/R4′ are hydrogen or one of R4 or R4′ is amino:
- o is 0 or 1;
- or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof.
7 more elements
Dependencies are inferred from the claim text.