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US 9,957,289 B2Granted
Compounds and methods for treating bacterial infections
AssigneeWashington University
InventorsJames W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
Life of this patent
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Abstract
The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
Claims14
A compound, the compound comprising Formula (IV):
- wherein:
- X is selected from the group consisting of hydrogen and OR2;
- R2 is independently selected from the group consisting of hydrogen, PO(OH)2, acetyl, COR5, CO(OR5), CO(CH2)nNR5R6, hydrocarbyl and substituted hydrocarbyl;
- n is an integer from 1 to 10;
- Z is O;
- Y is selected from the group consisting of O, CH(OH), CH(OR5), CHNR5R6, CH2, S, and NR5;
- R1 is selected from the group consisting of CH3, CF3, halogen, Cl, F, Br, I, OH, NH2, NR5R6, OCH3, CO2CH3, CONHCH3, alkyl, cyclopropyl, OR5, CO2R5, CONR5R6, hydrocarbyl, and substituted hydrocarbyl;
- R5 is selected from the group consisting of H and an optionally substituted alkyl, aryl, heterocycle, and cycloalkyl;
- R6 and R7 are selected from the group consisting of an optionally substituted alkyl, cycolalkyl, aryl, and heterocycle;
- R8 and R11 are independently selected from the group consisting of CONHCH3, COOCH3, COOH, CONH(heterocycle), heterocycle, H, alkyl, cyclopropyl, aryl, OR5, NR5R6, NR5COR6, NR5COOR6, NR5CONR6, NR5SO2R6, COR5, SO2R5, halogen, CN, NO2, COOR5, CONR5R6, NCOR7, NCONR7, NCOOR7, SO2NR5R6, and NHSO2R7;
- R12 is selected from the group consisting of H, alkyl, CH2R13, CH2COR13, CH2CONHR13, CH2CONHR13R14, CH2CONH(CH2)2R14, (CH2)2NR13, (CH2)nNR13, CH2COOH, CH2CONH(CH2)2NH2, and (CH2)2N(CH3)2;
- R13 is selected from the group consisting of —OH and an optionally substituted heterocycle, hydrocarbyl, and substituted hydrocarbyl;
- R14 is selected from the group consisting of alkyl and NH2.
10 more elements
Dependencies are inferred from the claim text.