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US 9,957,282 B2Granted
Crystalline forms of quinolone analogs and their salts
AssigneeSenhwa Biosciences, Inc.
InventorsDavid M. Ryckman, Iching Grace Yu, Hshiou-ting Liu
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Abstract
The present invention includes crystalline forms of 2-(4-Methyl-[1,4]diazepan-1-yl)-5-oxo-5H-7-thia-1,11b-diaza-benzo[c]fluorene-6-carboxylic acid (5-methyl-pyrazin-2-ylmethyl)-amide and crystalline forms of salts and/or solvates of 2-(4-Methyl-[1,4]diazepan-1-yl)-5-oxo-5H-7-thia-1,11b-diaza-benzo[c]fluorene-6-carboxylic acid (5-methyl-pyrazin-2-ylmethyl)-amide. Furthermore, the present invention provides compositions comprising the crystalline forms and therapeutic use of the crystalline forms and the compositions thereof.
Claims81
An isolated crystalline form of a Compound I:
- or a pharmaceutically acceptable salt thereof;
- wherein the isolated crystalline form of Compound I is:
- (a) a Polymorph A which is at least 90% pure;
- (b) a Polymorph C which is at least 90% pure;
- (c) a Polymorph E which is at least 90% pure;
- (d) a Polymorph G which is at least 90% pure;
- (e) a hydrochloric acid salt;
- (f) a maleic acid salt;
- (g) a fumaric acid salt;
- (h) a citric acid salt;
- or
- (i) an L-malic acid salt.
9 more elements
Dependencies are inferred from the claim text.