Benzodiazepine derivatives as RSV inhibitors

A compound represented by Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from the group consisting of:
• 1) Hydrogen;
• 2) Halogen;
• 3) CN;
• 4) Optionally substituted —C1-C8 alkyl;
• and
• 5) Optionally substituted —C1-C8 alkyl —O—R11;
• R2 and R5 are each independently selected from the group consisting of:
• 1) Hydrogen;
• and
• 2) Optionally substituted —C1-C8 alkyl;
• A is selected from the group consisting of:
• 1) Optionally substituted —C3-C12 cycloalkyl;
• 2) Optionally substituted —C3-C12 cycloalkenyl;
• 3) Optionally substituted aryl;
• and
• 4) Optionally substituted heteroaryl
• R3 is hydrogen or R11;
• R4 is selected from the group consisting of:
• 1) Optionally substituted —C3-C12 cycloalkyl;
• 2) Optionally substituted —C3-C12 cycloalkenyl;
• 3) Optionally substituted 3- to 12-membered heterocyclic;
• 4) Optionally substituted aryl;
• 5) Optionally substituted heteroaryl;
• 6) Optionally substituted aryl-O—;
• 7) Optionally substituted heteroaryl-O;
• 8) Optionally substituted aryl-C1-C4-alkyl;
• and
• 9) Optionally substituted heteroaryl-C1-C4-alkyl;
• wherein R4 is optionally substituted with 1 to 3 substituents independently selected from halo, —CH3, —CF3, —OCF3, —CN, —NH2, —OH, —CH2N(CH3)2, —C(O)CH3, —NH—(C1-C6)alkyl, —NH—(C1-C6)alkyl-(C1-C6)alkoxy, —SO2—(C1-C6)alkyl, —SO2—NH—(C1-C6)alkyl, —NH—SO2—(C1-C6)alkyl, 3- to 12-membered heterocyclic, aryl, heteroaryl, C1-C8-alkyl, C2-C8-alkenyl, C3-C8-cycloalkyl, C3-C8-cycloalkenyl, C1-C8-alkoxy, CH3OCH2—, CH3OCH2CH2O—,
• each R6 is independently selected from hydrogen, halogen, hydroxyl, protected hydroxyl, cyano, amino, protected amino, nitro, optionally substituted —C1-C8 alkyl, optionally substituted —C1-C8 alkoxy, optionally substituted —NHC1-C8 alkyl, optionally substituted —S—(—C1-C8 alkyl), optionally substituted —SO2—(—C1-C8 alkyl), -optionally substituted —SO2—NH—(—C1-C8 alkyl), optionally substituted —NH—SO2—(—C1-C8 alkyl), —CO2R12, —NR13R14, and —CO—NR13R14;
• R11 and R12 are each independently selected from the group consisting of:
• 1) Optionally substituted —C1-C8 alkyl;
• 2) Optionally substituted —C2-C8 alkenyl;
• 3) Optionally substituted —C2-C8 alkynyl;
• 4) Optionally substituted —C3-C8 cycloalkyl;
• 5) Optionally substituted —C3-C8 cycloalkenyl;
• 6) Optionally substituted 3- to 8-membered heterocyclic;
• 7) Optionally substituted aryl;
• and
• 8) Optionally substituted heteroaryl;
• R13 and R14 are each independently selected from hydrogen, optionally substituted —C1-C8-alkyl, optionally substituted —C2-C8-alkenyl, optionally substituted —C2-C8-alkynyl;
• optionally substituted —C3-C8-cycloalkyl, —C(O)R12, —S(O)2R12, and —S(O)2NHR12, and optionally substituted —C1-C8-alkoxy;
• alternatively, R13 and R14 are taken together with the nitrogen atom to which they are attached to form a heterocyclic ring;
• and n is 0, 1, 2, 3 or 4;
• and
• wherein each substituted R1, R2, R5, R6, R11, R12, R13, R14 and A is substituted by one or more substituents selected from deuterium, tritium, —F, —Cl, —Br, —I, —OH, protected hydroxy, —NO2, —CN, —NH2, —N3, protected amino, alkoxy, thioalkoxy, oxo, thioxo, —C1-C12-alkyl, —C2-C12-alkenyl, —C2-C12-alkynyl, —C3-C12-cycloalkyl-halo-C1-C12-alkyl, -halo-C2-C12-alkenyl, -halo-C2-C12-alkynyl, -halo-C3-C12-cycloalkyl, —NH—C1-C12-alkyl, —NH—C2-C12-alkenyl, —NH—C2-C12-alkynyl, —NH—C3-C12-cycloalkyl, —NH-aryl, —NH-heteroaryl, —NH-heterocyclic, -dialkylamino, -diarylamino, -diheteroarylamino, —O—C1-C12-alkyl, —O—C2-C12-alkenyl, —O—C2-C12-alkynyl, —O—C3-C12-cycloalkyl, —O-aryl, —O-heteroaryl, —O-heterocyclic, —C(O)—C1-C12-alkyl, —C(O)—C2-C12-alkenyl, —C(O)—C2-C12-alkynyl, —C(O)—C3-C12-cycloalkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)-heterocyclic, —CONH2, —CONH—C1-C12-alkyl, —CONH—C2-C12-alkenyl, —CONH—C2-C12-alkynyl, —CONH—C3-C12-cycloalkyl, —CONH-aryl, —CONH-heteroaryl, —CONH-heterocyclic, —OCO2—C1-C12-alkyl, —OCO2—C2-C12-alkenyl, —OCO2—C2-C12-alkynyl, —OCO2—C3-C12-cycloalkyl, —OCO2-aryl, —OCO2-heteroaryl, —OCO2-heterocyclic, —OCONH2, —OCONH—C1-C12-alkyl, —OCONH—C2-C12-alkenyl, —OCONH—C2-C12-alkynyl, —OCONH—C3-C12-cycloalkyl, —OCONH-aryl, —OCONH-heteroaryl, —OCONH-heterocyclic, —NHC(O)—C1-C12-alkyl, —NHC(O)—C2-C12-alkenyl, —NHC(O)—C2-C12-alkynyl, —NHC(O)—C3-C12-cycloalkyl, —NHC(O)-aryl, —NHC(O)-heteroaryl, —NHC(O)-heterocyclic, —NHCO2—C1-C12-alkyl, —NHCO2—C2-C12-alkenyl, —NHCO2—C2-C12-alkynyl, —NHCO2—C3-C12-cycloalkyl, —NHCO2-aryl, —NHCO2-heteroaryl, —NHCO2-heterocyclic, —NHC(O)NH2, —NHC(O)NH—C1-C12-alkyl, —NHC(O)NH—C2-C12-alkenyl, —NHC(O)NH—C2-C12-alkynyl, —NHC(O)NH—C3-C12-cycloalkyl, —NHC(O)NH-aryl, —NHC(O)NH-heteroaryl, —NHC(O)NH-heterocyclic, NHC(S)NH2, —NHC(S)NH—C1-C12-alkyl, —NHC(S)NH—C2-C12-alkenyl, —NHC(S)NH—C2-C12-alkynyl, —NHC(S)NH—C3-C12-cycloalkyl, —NHC(S)NH-aryl, —NHC(S)NH-heteroaryl, —NHC(S)NH-heterocyclic, —NHC(NH)NH2, —NHC(NH)NH—C1-C12-alkyl, —NHC(NH)NH—C2-C12-alkenyl, —NHC(NH)NH—C2-C12-alkynyl, —NHC(NH)NH—C3-C12-cycloalkyl, —NHC(NH)NH-aryl, —NHC(NH)NH-heteroaryl, —NHC(NH)NH-heterocyclic, —NHC(NH)—C1-C12-alkyl, —NHC(NH)—C2-C12-alkenyl, —NHC(NH)—C2-C12-alkynyl, —NHC(NH)—C3-C12-cycloalkyl, —NHC(NH)-aryl, —NHC(NH)-heteroaryl, —NHC(NH)-heterocyclic, —C(NH)NH—C1-C12-alkyl, —C(NH)NH—C2-C12-alkenyl, —C(NH)NH—C2-C12-alkynyl, —C(NH)NH—C3-C12-cycloalkyl, —C(NH)NH-aryl, —C(NH)NH-heteroaryl, —C(NH)NH-heterocyclic, —S(O)—C1-C12-alkyl, —S(O)—C2-C12-alkenyl, —S(O)—C2-C12-alkynyl, —S(O)—C3-C12-cycloalkyl, —S(O)-aryl, —S(O)-heteroaryl, —S(O)-heterocyclic —SO2NH2, —SO2NH—C1-C12-alkyl, —SO2NH—C2-C12-alkenyl, —SO2NH—C2-C12-alkynyl, —SO2NH—C3-C12-cycloalkyl, —SO2NH-aryl, —SO2NH-heteroaryl, —SO2NH-heterocyclic, —NHSO2—C1-C12-alkyl, —NHSO2—C2-C12-alkenyl, —NHSO2—C2-C12-alkynyl, —NHSO2—C3-C12-cycloalkyl, —NHSO2-aryl, —NHSO2-heteroaryl, —NHSO2-heterocyclic, —CH2NH2, —CH2SO2CH3, -aryl, -arylalkyl, -heteroaryl, -heteroarylalkyl, -heterocyclic, —C3-C12-cycloalkyl, polyalkoxyalkyl, polyalkoxy, -methoxymethoxy, -methoxyethoxy, —SH, —S—C1-C12-alkyl, —S—C2-C12-alkenyl, —S—C2-C12-alkynyl, —S—C3-C12-cycloalkyl, —S-aryl, —S-heteroaryl, —S-heterocyclic, methylthiomethyl, or -L′-R′, wherein L′ is C1-C6alkylene, C2-C6alkenylene or C2-C6alkynylene, and R′ is aryl, heteroaryl, heterocyclic, C3-C12cycloalkyl or C3-C12cycloalkenyl.