Process for the preparation of intermediates useful in the preparation of Hepatitis C virus (HCV) inhibitors
AssigneeLaurus Labs Limited
InventorsKirshna R. Yalamareddy, Clifton Leigh, Sankar Subramanian, Stephen Mccarron, Omar Depaolis, Lyndon Marble
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Abstract
The present invention generally relates to a process for preparation of 9-halo-3-(2-haloacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one of Formula I, which is an intermediate in the preparation of Hepatitis C Virus (HCV) inhibitors.
Claims32
A process for the preparation of a compound of Formula I comprising:
- a) reacting a compound of Formula II with a compound of Formula III to obtain a compound of Formula IV, where the compound of Formula II is,
- wherein the compound of Formula III is,
- wherein the compound of Formula IV is,
- wherein ‘X’ represents a halogen;
- b) converting the compound of Formula VI into the compound of Formula I, wherein the compound of Formula I is
A process for the preparation of a compound of Formula I comprising:
- a) reacting a compound of Formula II with a compound of Formula III to obtain a compound of Formula IV, where the compound of Formula II is,
- wherein the compound of Formula III is,
- wherein the compound of Formula IV is,
- wherein ‘X’ represents a halogen;
- b) cyclizing the compound of Formula IV to obtain a compound of Formula V, wherein the compound of Formula V is,
- c) converting the compound of Formula V into the compound of Formula I, wherein the compound of Formula I is
A process for the preparation of a compound of Formula I comprising:
- a) reacting a compound of Formula II with a compound of Formula III to obtain a compound of Formula IV, where the compound of Formula II is,
- wherein the compound of Formula III is,
- wherein the compound of Formula IV is,
- and
- wherein ‘X’ represents a halogen;
- b) cyclizing the compound of Formula IV to obtain a compound of Formula V, wherein the compound of Formula V is,
- c) converting the compound of Formula V into a compound of Formula VI, where the compound of Formula VI is,
- and
- d) converting the compound of Formula VI into the compound of Formula I, wherein the compound of Formula I is
A process for the preparation of a compound of Formula Ia comprising:
- a) reacting a compound of Formula IIa with a compound of Formula III to obtain a compound of Formula IVa, wherein the compound of Formula IIa is
- wherein the compound of Formula III is
- and
- wherein the compound of Formula IVa is
- b) cyclizing the compound of Formula IVa to obtain a compound of Formula V, wherein the compound of Formula V is
- c) converting the compound of Formula V into a compound of Formula VI, wherein the compound of Formula VI is
- and
- d) converting the compound of Formula VI into the compound of Formula Ia, wherein the compound of Formula Ia is
A compound of Formula IV, wherein ‘X’ represents a halogen, and wherein the compound of Formula IV is
Dependencies are inferred from the claim text.