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US 9,957,272 B2Granted
3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
AssigneesVictoria Link Limited, Albert Einstein College of Medicine
InventorsGary Brian Evans, Alistair Ian Longshaw, Vern L. Schramm, Peter Charles Tyler
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Abstract
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
Claims8
A compound of the formula (Ia):
- where:
- X is ethyl;
- A is CH;
- B is NH2 or NHR5;
- R5 is an alkyl, alkenyl, alkynyl, aralkyl, aralkenyl, aralkynyl, or aryl group, each of which is optionally substituted with one or more halogen or hydroxy groups;
- and
- D is H, OH, NH2, or SCH3;
- or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester prodrug form thereof.
5 more elements
Dependencies are inferred from the claim text.